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Pycnogenol treatment resulted in more normal-looking sperm. Joe Cohen flipped the script on conventional and alternative medicine and it worked. This study adds to a body of research showing the benefits of Pycnogenol for improving circulation and blood flow, strengthening the vascular system and managing cholesterol. Pycnogenol is a standardized supplement formula guaranteed to contain at least 65-75% proanthocyanidins, the active . (3), Ototoxicity is ear poisoning and can occur when exposed to certain drugs or chemicals, such as cisplatin, that damage the inner ear or the vestibulocochlear nerve. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for treating conventional diabetes may be beneficial. The combination of Panax ginseng and vitamin E also appears to have an effect. A study of 58 people with high blood pressure suggests that even lower doses (100 mg/day) may improve blood vessel health and reduce markers of high blood pressure (endothelin-1) after 12 weeks. Score one for diabetes control and fewer risk factors for the heart. (2004). However, this was a relatively small study, so larger ones are needed to fully understand pine bark extracts role in these findings. So it . It has many health benefits, and may help protect against several chronic conditions. In 22 German heavy smokers, platelet aggregation was prevented by 500 mg of aspirin or 100 mg Pycnogenol. If you are thinking of taking Pycnogenol for a serious health condition like asthma or high blood pressure, check with your doctor., People who have autoimmune conditions like multiple sclerosis or lupus should talk to their doctor before trying Pycnogenol. Its been noted that taking OPCs and vitamin C supplements at the same time could increase blood pressure if you have hypertension. Theres some evidence that Pycnogenol acts similar to a sustained-release formulation. In the study, it reduced cold symptoms and complications, the number of lost working days, and the use of over-the-counter medications compared to those who did not supplement with the extract [60]. Our website services, content, and products are for informational purposes only. Pycnogenol is a compound of natural chemicals. Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease caused primarily by tobacco use. While it may seem intimidating at first, counting macros is a common Erythritol is now one of the most popular natural zero-calorie sweeteners available. In one trial of 77 people with type 2 diabetes, pycnogenol (100 mg/day) for 12 weeks lowered both blood sugar levels and HbA1c, a marker of long-term blood glucose levels [31]. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. It also reduced LDL cholesterol at a slightly lower dose (125 mg/day) in those with type 2 diabetes in a clinical trial of 48 people after 12 weeks. In a good-quality study, 77 patients with osteoarthritis were treated with 100 mg of Pycnogenol daily and 79 patients were treated with placebo for three months. COPD. Anal Fissures - FULL HEALTH SECRETS Unlike drug manufacturers, the makers of supplements dont have to show their products are safe or effective before selling them on the market. The 2012 study on the anti-aging benefits of Pycnogenol is commonly-cited by anti-aging supplement manufacturers. Pycnogenol (200 mg/day) may reduce muscle cramps and pain according to a study of 66 healthy people, athletes, and those with venous problems after 4 weeks. It also seems to help with cell regeneration and replication. According to a study of 11 patients with lupus, pycnogenol may reduce symptoms, inflammation, and oxidative stress [54]. Vinpocetine is a well-known substance in the health-hacking community with a variety of claimed health benefits. Too much pressure signals that your heart might be working too hard. But what are its health benefits? Pycnogenol: Health Benefits, Uses, Doses, Safety Information - WebMD In one study, 10 patients were treated with placebo and 30 patients were treated with Pycnogenol (100 mg twice or three times daily for two months). Note that the numbers in parentheses (1, 2, etc.) While OPCs found in this extract are mostly known for their antioxidant-producing benefits, these amazing compounds exude antibacterial, antiviral, anticarcinogenic, anti-aging, anti-inflammatory and anti-allergic properties. We take a look at what the science actually says. Prenatal nutrition can be confusing. (2017). A number of clinical trials suggest that Pycnogenol may lower blood glucose if taken daily for at least 12 weeks. The Benefits of DIM. Helps Increase Athletic Performance. A combination product with Pycnogenol (Lady Prelox) improved sexual function in a clinical trial of 83 healthy postmenopausal women after 8 weeks. In a small/preliminary study of kids with asthma, pycnogenol helped improve symptoms. 1. These antioxidants scavenge those damaging free radicals in an effort to eliminate them, ultimately preventing disease. 6 Vinpocetine Benefits + How It Works & Side Effects Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. Another study found this supplement can even halt progression of vision . A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. According to the lab results of 10 volunteers, a higher Pycnogenol dose (300 mg) may impact these enzymes after just 30 minutes [52]. If you knew you could resolve your erectile dysfunction and, therefore, naturally remedy impotence issues, wouldnt you? Pycnogenol (100 mg/day) given to 44 older healthy people with high oxidative stress improved cognitive function, attention, mental performance, and reduced oxidative stress after 12 months [21]. Benefits of Pycnogenol - Healthy Directions Regardless, a natural option is available and far worth the wait. A study was conducted by the Guang An Men Hospital of Chinese Medical Science Research Institutewith 77 diabetes type II patients to determine if theextract of the French Maritime pine bark provided anti-diabetic effects. Pycnogenol: French maritime pine bark extract Forty-seven Japanese men with mild erectile dysfunction were given supplementation L-arginine and French maritime pine bark extract over a period of time. The researchers of the study propose that pycnogenol may reduce pain and cramps during retraining and rehabilitation in people with blood vessel problems [11]. Pycnogenol Review - Worlds Best Anti-Aging Supplement? (14, 15). Pycnogenol (100 mg/day) may reduce hay fever symptoms, according to a clinical trial of 39 people. Pine bark extract may be the perfect treatment since its an antioxidant dynamo. It has been studied for its effects on everything from mental function to treating high blood pressure. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. Known for its antioxidant properties, Pycnogenol offers a wide range of potential health benefits. Most anal fissures heal with home treatment after a few days or weeks. Moreover, Pycnogenol lowered the chemical, leukotrienes responsible for asthma attacks. For diseases of the retina, including those related to diabetes: 50 milligrams three times daily. ", Panminerva Medica: "Supplementation with Pycnogenol improves signs and symptoms of menopausal transition.". High levels of both of these are considered risk factors for heart disease. The first studied group included 66 healthy subjects in whom the number of muscle cramps was recorded two weeks before entering the study and during the fourth and fifth week. If a blood clot blocks the normal blood flow, it is known as thrombosis. Several studies show how Pycnogenol helps block platelet formation and thus helps prevent thrombosis. Today's Dietitian: "Pycnogenol Supplement Offers Promise for Managing a Variety of Conditions." Learn more. The study concluded that Pycnogenol can prevent cramps, muscular pain at rest, and pain after/during exercise healthy people or those with diabetes or claudication. There's good evidence that pycnogenol helps with eye damage caused by diabetes. It also appeared to improve their attention span, visual motor skills, and concentration. For most people, pine bark extract doesnt cause any side effects. Some people seek to manage ADHD symptoms through an ADHD diet. We do not aim to diagnose, treat, cure or prevent any illness or disease. The . In one human study, some of the reported side effects of chanca piedra supplementation included: abdominal pain. First and foremost, start eating an anti-inflammatory Local Raw Honey (Bee Pollen) Considering how good it tastes, having some raw honey Apple Cider Vinegar (ACV) You can now find high-quality apple cider vinegar in . Dr. Steven Lamm did a great job at explaining the new benefits of pycnogenol. Moreover, Pycnogenol group either reduced or discontinued the use of asthma drugs. Herbal supplements are not regulated by the Food and Drug Administration (FDA), so they may not be up to the same safety standards as medications that have gone through clinical testing and drug trials. A 2021 review in the Arab Journal of Urology listed it first among "promising herbal remedies" for ED. This supplement may also increase muscle endurance and performance after a single pre-exercise dose according to a study of 9 cyclists [12, 13]. Are there any risks to taking it? Infants and children may not be able to synthesize enough of it, but it is present in many protein-rich . A combination supplement (pycnogenol with collagen, coenzyme Q10, and other ingredients) reduced skin aging, elasticity, hydration, and tonicity in a study of 30 women [65]. A study of 66 healthy adults found that Pycnogenol may reduce the number of leg cramps experienced [11]. New studies show Pycnogenol can prevent or reverse the oxidative damage that produces blood vessel disease 4, metabolic syndrome 20, diabetes 20,24, and neurodegenerative disorders 23,24. Benefits Of Pycnogenol To Live Longer - Life Extension Pycnogenol and Pine Bark Extract Supplements. Protection from inflammation, immunosuppression and carcinogenesis Align your health hacks with your genes for optimal health & cognitive function. ", Journal of Medicinal Food: "Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for . All rights reserved. More specifically, because it strengthens the capillaries in the retina, Mirtogenol can help prevent retinopathy. Pycnogenol (125 mg/day) had the same effects in another study of 48 people with diabetes and high blood pressure. However, research on these two groups is limited [71, 15]. A randomized, double-blind, placebo-controlled study of 60 patients aged six to 18 years old, was conducted over three months during which patients were randomly assigned to receive either Pycnogenol or placebo. It also may enhance swimming, biking, and running scores in professional athletes preparing for a triathlon (at 150 mg/day). Traditionally, people might drink a brew made from pine bark -- rich in pycnogenol -- as a treatment. blood in the urine. painful urination. All Pycnogenol-treated patients responded favorably in contrast to placebo treatment. Pine bark extract has been studied regarding its relationship to exercise performance, oxidative stress and inflammation to body that has been imposed by exercise. Its quality is specified in the United States Pharmacopeia [3]. Research into Pycnogenol has revealed some promising results in over 30 health conditions. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. ", Natural Medicines Comprehensive Database web site: "Pycnogenol.". Optimal doses of pycnogenol have not been set for any condition. Typical doses range from 50 milligrams to 450 milligrams per day. You can find out your systolic blood pressure by looking at the top number of a blood pressure test. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Four hundred years later, a French researcher named Jacques Masquelier did some studies to understand why this natural remedy was so effective. Skin irritation. Proper nutrition is essential for ADHD treatment. As a skin cream, its safe to use for about seven days. If you take any medications regularly, talk to your doctor before you start using pycnogenol supplements. However, some of these other pine bark extracts can have different active compounds, which may affect their biological activity. 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The women taking Pycnogenol also experienced improvement in fatigue, sleep, concentration, memory, dizziness, and mood, including less irritability. In another study, 61 children with ADHD were given one mg per kg/day of Pycnogenol or placebo over four weeks. Last medically reviewed on January 24, 2018. It also provides powerful antioxidant protection and helps inhibit inflammatory factors to support. Top Anti-Aging Properties Of Pycnogenol - Life Extension The flesh of the grape contains approximately 1/20th-1/100th of the total antioxidant capacity of the seed or the skin. are clickable links to medically peer-reviewed studies. (11, 12), While both eliminate pain, the pine bark extract is a far better choice. What Are These Tiny Red Spots on My Skin (Petechiae)? You may want to start slow, taking smaller amounts, to ensure that your body works well with the OPCs found in pine bark extract. Its used as a natural supplement for several conditions, including dry skin and ADHD. During week, five without, treatment, reduction of cramps was maintained in all three groups. Finally, research suggests that Pycnogenol may improve triathlon time while possibly reducing cramps and post-running pain [10]. Disclaimer: Results are not guaranteed*** and may vary from person to person***. For mild high blood pressure: 200 milligrams daily. During the first month on L-arginine, only five percent of patients experienced normal erection. Additionally, the results showed that the extract has significant anti-pseudomonas activity, making it a potential natural remedy and possible preventive measure for infections. A sitz bath, which involves sitting in warm water for 10 minutes, twice daily, is helpful to patients with anal itching, aching or burning and is known as one of the best ways to get rid of hemorrhoids fast. A trial of children with ADHD found that Pycnogenol may improve attention, possibly by increasing the total antioxidant status and reducing DNA damage. (1, 2). Boost gastrointestinal health. However, its unclear how clinically effective Pycnogenol is for most of these conditions due to the low quality of evidence. A 2004 animal study also found that applying a gel containing pine bark extract sped up the wound-healing process. What Is Pycnogenol, and What's It Used For? - Wonder Labs With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli . It also may increase the activity of genes that make collagen and hyaluronic acid in the body [64]. Some risks associated with Pycnogenol include:, Pycnogenol and other maritime tree barks have not been studied as extensively as traditional medicine. The goal of one study was to evaluate whether or not Pycnogenol could prevent edema (fluid build-up) during long-haul flights in healthy people. Risks. It does this by improving the time it takes the body to reach a fatigued state through increased serum NAD+ levels. Chestnut seed extract did not do as well. The New Pycnogenol Benefits | Dr. Steven Lamm - YouTube (2013). It also may help those on blood pressure medications to reduce their dose [32]. A total of 40 patients with retinopathy (damage to the retina part of the eye) from diabetes and other vascular causes were enrolled in one study. Any medication that you take, including herbal supplements, comes with certain risks. 7 Pine Bark Extract Benefits - LongLifeNutri Commonly called arthritis, osteoarthritis is caused when the cartilage on your joints begins to wear down. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. However, it can also be used topically. Studies were conducted in Turkey on subjects who underwent abdominal surgery to determine if the pine bark extract could help reduce the inflammation. According to a study in 59 cancer patients, Pycnogenol (150 mg/day) may reduce side effects associated with radiation or chemotherapy, including mouth soreness and ulcers, mouth and eye dryness, nausea, vomiting, diarrhea and weight loss [78]. A clinical trial of 57 ADHD children found that daily Pycnogenol (1 mg/kg) for one month may reduce hyperactivity symptoms. Grape seed extract may have heart-health benefits. In one study, 200 mg a day of Pycnogenol taken three hours prior to the first cigarette for the day for two months significantly reduced cigarette-induced platelet aggregation. In 24 people with early eye damage from diabetes, Pycnogenol improved vision, reduced eye swelling, and improved circulation in the eye after 2 months. Gotu Kola: Health Benefits, Side Effects, Uses, and More - WebMD Pycnogenol has been shown to help relieve the pain associated with osteoarthritis by keeping blood chemicals from attacking the cartilage. Rakel, D. Integrative Medicine, 3rd edition, Saunders, 2012. According to a large analysis, Pycnogenol may reduce osteoarthritis symptoms and pain short-term [45, 46]. Once youre sure that you dont have any negative reactions, you may be able to increase your dosage according to the label. However, it is also important to see beyond the pyncogenol marketing campaign and understand the possible dangers associated with this natural supplement. (8). Studies have shown that the tree bark can help decrease common symptoms including hot flashes, mood swings, irregular periods, and others. Pycnogenol is the registered trademark name for a French formula. A 2015 review indicates that pine bark extract can be used to treat metabolic syndrome and related disorders such as obesity, diabetes, and high blood pressure. 14 Health Benefits of Pine Bark Extract - Blog - iHerb.com It is found primarily in southwestern France and is used to help people with asthma, allergies, hay fever, and other health conditions.. The most effective blood sugar-lowering dose was 200 mg/day higher doses had no further benefit [33]. Sort By. There are also several other natural ADHD remedies you can try. Pycnogenol: Health Benefits, Side Effects, Uses, Dose - RxList WebMD does not provide medical advice, diagnosis or treatment. PQQ Supplements: Overview, Benefits, and Side Effects - Healthline There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions. Pycnogenol lowered leukotrienes as well. This study adds to a body of research showing the benefits of Pycnogenol . In the control group, there were five thrombotic events; whereas the Pycnogenol-treated subjects only experienced nonthrombotic, local flare-ups. Researchers suggest that it may epigenetically turn off genes responsible for joint damage (ADAMTS) as well as reduce inflammation enzymes (MMP3) and cytokines (IL 1-beta) [47, 48]. Although the preliminary studies show many health benefits with the use of Pycnogenol, future larger and better studies are needed. , Allergy: "Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. All included participants had subclinical cognitive impairment, which looks like typical brain fog [22]. In another good study, 48 patients with diabetes and high blood pressure on ACE inhibitors were randomized to receive either Pycnogenol 125 mg daily or placebo for 12 weeks. If youre wondering how to get an even skin tone, there are plenty of remedies that can help. Learn about this tree-based pill and how it might be able to help you. A randomized clinical trial of 30 people found that Pycnogenol (150 mg/day) may help heal vein ulcers from surgery and reduce swelling after 3 months of treatment [25]. A study of 30 women found that Pycnogenol (75 mg/day) may reduce the skin area affected by melasma as well as lower symptoms of fatigue, constipation, body pain, and anxiety [62]. Start with a low dose so you can be sure it doesnt cause any side effects. But a month after pycnogenol was stopped, the symptoms came back, suggesting that it may need to be used regularly to achieve the benefits [41]. In theory, pine bark may lower blood pressure and blood sugar level, and these effects have also been reported in some RCTs. SelfDecode is a personalized health report service, Upset stomach. Extracts can also be made from other pine barks, such as Pinus radiata, Pinus densiflora, Pinus thunbergii, and Pinus massoniana. Is Garcinia Cambogia Safe for Weight Loss? A trial of 132 people found that Pycnogenol (150 mg/day) may improve risk factors of metabolic syndrome including lowering triglyceride levels, blood pressure, and fasting glucose, decreasing waist circumference, and increasing HDL cholesterol levels [29]. Additionally, athletes have endured less cramping and muscle pain when using the extract. The study participants symptoms started to return a month after they stopped taking pine bark extract. It is standardized to contain 65-75% procyanidins, a class of polyphenols and flavonoids like those found in blueberries, wine, grape skin, citrus, and cocoa. Add to Cart. Rating: 100%. All rights reserved. In a good-quality study, 24 adults aged 24 to 53 years old with attention deficit hyperactivity disorder (ADHD) were given Pycnogenol, placebo, or the standard drug for three weeks. The Best Supplements for Healthy Digestion, How to Get the Protective Power of Vitamin K. It may cause side effects such as: Risks. All of our content is written by scientists and people with a strong science background. Pycnogenol-treated subjects experienced an improvement in all menopausal symptoms. Pycnogenol: Skin, ADHD, Other Uses, Side Effects - Healthline In oneparticular study published in Research in Pharmaceutical Sciences, researchers investigated the antibacterial activity of pine bark extract essential oil on staph infections, E. coli and pseudomonas infections. Add to Cart. With time, the participants were able to handle more UV radiation without experiencing skin damage [63]. Mental function. Natural Factors Pycnogenol 25mg 60 Veggie Caps. Natural Factors Pycnogenol 100mg 30 Veggie Caps. Rare cases of liver disease. Pain score in the Pycnogenol-treated group was reduced by 56%, as compared to 9.6% reduction in the placebo group. - Please read carefully and implement principles included in the Health Recovery Plan. Pine bark extract provides many benefits to the skin, including reducing the signs of aging. This condition is due to the pooling of blood in the veins of the lower legs. Pycnogenol; Pycnogenol. According to some researchers, Pycnogenol may lower blood pressure by relaxing blood vessels, reducing free radicals, and lowering inflammation. Pycnogenol has four main components that contribute to its benefits for men's health. Pine bark extract can make a great addition to your nutritional arsenal for its potent antioxidant support, as well as its added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support. Considering that about 1 of 3 adults in the U . Forty patients were treated with either 600 mg chestnut seed extract a day or 360 mg Pycnogenol a day over a period of four weeks. There is insufficient evidence to support the use of Pycnogenol for any of the uses listed below. from the bark of the French maritime pine tree. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. People who use the supplement along with their traditional medication usually take smaller doses than those who only take the supplement. Pine bark extract is composed of 80% to 85% proanthocyanidins, the monomers catechin and taxifolin (5%), and phenolic acids, including derivatives of benzoic and cinnamic acids (2% to 4%). 7. DIM and other plant indoles are found in . Flavonoids and proanthocyanidins within these fruits can . Pycnogenol is known under different names in some countries, such as Oligopin, and Flavangenol in Japan [4, 5]. Pycnogenol led to a reduction of muscle cramps from 4.8 a week to 1.3 at week four. Another study of 47 women found that supplementing with 30 mg Pycnogenol twice daily for over 1 month may reduce menstrual pain [73]. Here are 12 benefits of ginkgo biloba. Because of its anti-inflammatory effects, nattokinase has been used to help with pain from arthritis, including that of rheumatoid arthritis. This includes supporting healthy blood circulation, acting as a natural anti-inflammatory, helping to generate collagen and hyaluronic acid for improved skin health and aiding in the production of endothelial nitric oxide which helps to dilate blood . Another clinical trial of 76 people with allergic asthma also suggests that Pycnogenol may reduce IgE antibodies and asthma symptoms [18, 16]. , Improves Symptoms Associated With Menopause, A number of women experience physical discomfort due to symptoms of menopause. Headaches. Potential for allergy when taken orally or used on the skin. In a clinical trial of 92 people with tinnitus, or ringing in the ears, Pycnogenol (100-150 mg/day) helped reduce symptoms and improve blood flow in the ears after 4 weeks [80]. - Apply a hot compress to the anus or soaking it in a shallow tub of hot water several times a day. For most people, pine bark extract doesn't cause any side effects.